Hideo Kojima says he would consider making a sequel to Death Stranding but it probably wouldn’t continue on from the first game.
In an interview with Vulture, Hideo Kojima discussed the possibility of working with Norman Reedus again, and that if he did it could be a sequel to Death Stranding. That said, if he were to start such a project, Kojima says he “would start from zero.”
What that presumably means is that a second game wouldn’t continue any plot points on from the first game. Perhaps the two games would be connected by sharing the same universe or exploring similar themes instead.
Source: IGN Video Games All